Kanamycin kinase

kanamycin kinase
Identifiers
EC number 2.7.1.95
CAS number 62213-36-9
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a kanamycin kinase (EC 2.7.1.95) is an enzyme that catalyzes the chemical reaction

ATP + kanamycin \rightleftharpoons ADP + kanamycin 3'-phosphate

Thus, the two substrates of this enzyme are ATP and kanamycin, whereas its two products are ADP and kanamycin 3'-phosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:kanamycin 3'-O-phosphotransferase. This enzyme is also called neomycin-kanamycin phosphotransferase.

Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1J7I, 1J7L, 1J7U, 1L8T, 1ND4, 2B0Q, and 2BKK.

References